Natives are great for hedges! Most species only need a little water to get established and then can be left on their own. They often attract birds and other wildlife and can be very deer proof. There are other natives that can be used for these purposes but we have found these to be the most effective.
These plants are good for giving you privacy from the neighbors or keeping their not-so-tidy yards out of your view. They can also be good for blocking future traffic. You can't stop traffic with a 6 inch tall plant so make sure it is well protected till it can protect itself. Or along these same lines they can be used to keep out trespassers. These plants are also good for hiding ugly fences or walls.
There are lots of good Ceanothus for hedges. They are evergreen, colorful, and grow fast. Make sure you pick the right plant for your soil. Some Ceanothus prefer sand and some clay. DON'T PUT THESE ON DRIP! or they will be leggy, short lived, unhealthy and more susceptible to deer.